Vitamin B12 bioconjugates as chemiotherapic agents

An increased uptake of vitamin B12 has been observed in rapidly proliferating cells such as cancer cells. The functionalisation of vitamin B12 with groups of diagnostic and/or therapeutic interes is a potential strategy to selectively deliver agents into tumor cells, to be exploited as contrast agents for MRI (Gd3+, 111In3+) or for applications in neutron capture therapy (BNCT).

 

 
 

Transcobalamin Structure

PNAS 2006, 103 (12), 4386

  

CNCbl-DTPA-Gd

Chem. Eur. J. 2009, 15 (32), 7980

Last update: 08-16-2019 - 19:50