30/10 alle ore 11.00 si terrà un seminario su "Peptide based nanostructures for biomedical applications", Sala del Consiglio, edificio C11 (primo piano)

Tipologia evento: 
home
Data evento
Data inizio evento: 
30/10/2018 - 11:00
Data fine evento: 
30/10/2018 - 13:15
Data pubblicazione evento
Pubblicato il: 
28/10/2018

Peptide based nanostructures for biomedical applications

Antonella Accardo Department of Pharmacy – University of Naples “Federico II”

 

Self-assembly via bottom-up approch is an increasingly attractive tool for the fabrication of novel nanomaterials for a broad range of applications. Among all the natural building blocks proposed for the bottom-up approach, amino acids and peptides open very large prospective for the design and the generation of complex supramolecular architectures.1 Peptides have well-known advantages ranging from high versatility, intrinsic biocompatibility, possibility of functionalization pre- and post-aggregation to high synthetic accessibility and convergence, low immunogenicity and relative low cost. In the present communication, it is reported an overview on different peptide based nanostructures (liposomes, micelles, inverse mesophases and nanofibers) and on the potential applications in nanomedicine as theranostic platforms,2 bioimaging tools (Magnetic Resonance Imaging3,4 and in the fluorescence imaging5) and tissue engineering.6 With the aim to improve biomedical and functional performance of these materials, the structural organization of the peptide builing blocks in the nanoarchitecture has been deeply investigated.

 

References

  1. L. Sun, et al. Int. J. Nanomedicine 2017,12, 73-86
  2. A. Accardo et al. Polymer J. 2013, 45(5), 481-493
  3. A. Accardo et al.  Coord. Chem. Rev. 2009, 253(17-18), 2193-2213
  4. C. Diaferia et al. Adv. Fuct. Mater. 2015, 25(45), 7003-7016
  5. C. Diaferia et al. Chemistry Eur J. 2016, 22(46), 16586-16597
  6. C. Diaferia et al. Chemistry Eur J. 2018, 24(26), 6804-6817
Ultimo aggiornamento: 29-10-2018 - 09:20
Share/Save