Vitamin B12 bioconjugates as chemiotherapic agents
Research Area:
An increased uptake of vitamin B12 has been observed in rapidly proliferating cells such as cancer cells. The functionalisation of vitamin B12 with groups of diagnostic and/or therapeutic interes is a potential strategy to selectively deliver agents into tumor cells, to be exploited as contrast agents for MRI (Gd3+, 111In3+) or for applications in neutron capture therapy (BNCT).
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Transcobalamin Structure PNAS 2006, 103 (12), 4386 | CNCbl-DTPA-Gd Chem. Eur. J. 2009, 15 (32), 7980 |
Research Group
Vitamin B-12 chemotherapeutic agents Group |
Last update: 08-30-2024 - 21:50