Linea di ricerca "Sviluppo di complessi metallici per applicazioni in diagnostica e terapia"

Pubblicazioni pertinenti dal 2009

1) T. Gianferrara, I. Bratsos, E. Alessio*

A Categorization of Metal Anticancer Compounds Based on Their Mode of Action.

Dalton Trans., 2009, 7588-7598. Perspective Article

2) T. Gianferrara, I. Bratsos, E. Iengo, B. Milani, A. Oštrić, C. Spagnul, E. Zangrando, E. Alessio*

Synthetic strategies towards ruthenium-porphyrin conjugates for anticancer activity.

Dalton Trans., 2009, 10742-10756.

3) T. Gianferrara, A. Bergamo, I. Bratsos, B. Milani, C. Spagnul, G. Sava, E. Alessio

Ruthenium-porphyrin conjugates with cytotoxic and phototoxic antitumor activity.

J. Med. Chem., 2010, 53, 4678-4690.

4) I. Bratsos, T. Gianferrara, E. Alessio,* C. G. Hartinger, M. A. Jakupec, B. K. Keppler

Ruthenium and Other Non-platinum Anticancer Compounds.

in Bioinorganic Medicinal Chemistry, E. Alessio ed., Wiley-VCH, Weinheim, 2011, pp. 151-174.

5) I. Bratsos,* D. Urankar, E. Zangrando, P. Genova-Kalou, J. Košmrlj, E. Alessio, I. Turel*

1-(2-picolyl)-substituted 1,2,3-triazole as novel chelating ligand for the preparation of ruthenium complexes with potential anticancer activity.

Dalton Trans. 2011, 40, 5188 – 5199.

6) I. Bratsos,* C. Simonin, E. Zangrando, T. Gianferrara, A. Bergamo, E. Alessio*

New half sandwich-type Ru(II) coordination compounds characterized by the fac-Ru(dmso-S)₃ fragment: influence of the face-capping group on the chemical behavior and in vitro anticancer activity.

Dalton Trans. 2011, 40, 9533 – 9543.

7) I. Bratsos,* E. Mitri, F. Ravalico, E. Zangrando, T. Gianferrara, A. Bergamo, E. Alessio*

New half sandwich Ru(II) coordination compounds for anticancer activity

Dalton Trans. 2012, 41, 7358 – 7371.

8) A. Rilak, I. Bratsos,^* E. Zangrando, J. Kljun,I. Turel, Ž. D. Bugarčić, E. Alessio*

Factors that influence the antiproliferative activity of half sandwich Ru^II-[9]aneS3coordination compounds: activation kinetics and interaction with guanine derivatives.

Dalton Trans. 2012, 41, 11608 – 11618.

9) G. Ragazzon, I. Bratsos, E. Alessio,* L. Salassa,*A. Habtemariam, R. McQuitty, G. J. Clarkson, P. J. Sadler*

Design of Photoactivatable Metallodrugs: Selective and Rapid Light-induced Ligand Dissociation from Half-Sandwich [Ru([9]aneS 3 )(N–N')(py)]²+ Complexes.

Inorg. Chim. Acta 2012, 393, 230-238.

10) C. Spagnul, R. Alberto,* G. Gasser, S. Ferrari, V. Pierroz, A. Bergamo, T. Gianferrara,* E. Alessio

Novel water-soluble ^99mTc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging.

J. Inorg. Biochem. 2013, 122, 57–65.

11) I. Finazzi, I. Bratsos, T. Gianferrara, A. Bergamo, N. Demitri, G. Balducci, E. Alessio*

Photolabile Ru^II Half-Sandwich Complexes Suitable for Developing “Caged” Compounds: Chemical Investigation and Unexpected Dinuclear Species with Bridging Diamine Ligands.

Eur. J. Inorg. Chem. 2013, 4743–4753. DOI:10.1002/ejic.201300792

12) J. Kljun,I. Bratsos, E. Alessio, G. Psomas, U. Repnik, M. Butinar, B. Turk, I. Turel*

New Uses for Old Drugs: Attempts to Convert Quinolone Antibacterials into Potential Anticancer Agents Containing Ruthenium.

Inorg. Chem. 2013, 52, 9039–9052. DOI: 10.1021/ic401220x

13) T. Gianferrara, C. Spagnul,R. Alberto,^* G. Gasser,S. Ferrari, V. Pierroz, A. Bergamo, E. Alessio*

Towards matched pairs of porphyrin-Re(I)/^99mTc(I) conjugates that combine photodynamic activity with fluorescence- and radio-imaging.

ChemMedChem 2014, 9, 1231–1237.DOI: 10.1002/cmdc.201300501.

14) A. Rilak, I. Bratsos,* E. Zangrando, J. Kljun, I. Turel, Ž. D. Bugarčić, E. Alessio*

New Water-Soluble Ruthenium(II) Terpyridine Complexes for Anticancer Activity: Synthesis, Characterization, Activation Kinetics, and Interaction with Guanine Derivatives.

Inorg. Chem. 2014, 53, 6113–6126. DOI 10.1021/ic5005215.

15) S. Pillozzi, L. Gasparoli, M. Stefanini, M. D’Amico, M. Ristori, E. Alessio, F. Scaletti, A. Becchetti, A. Arcangeli*, L. Messori*

NAMI-A is Highly Cytotoxic Toward Leukaemia Cell Lines: Evidence of Inhibition of KCa3.1 Channels.

Dalton Trans. 2014, 43, 12150 – 12155. DOI:10.1039/C4DT01356E.

Linea di ricerca "Sviluppo di complessi metallici per fotocatalisi e per la costruzione di sistemi supramolecolari"

Pubblicazioni pertinenti dal 2009

1) E. Zangrando, N. Kulisic, F. Ravalico, I. Bratsos, S. Jedner, M. Casanova, E. Alessio*

 New ruthenium(II) precursors with the tetradentate sulfur macrocycles tetrathiacyclododecane ([12]aneS4) and tetrathiacyclohexadecane ([16]aneS4) for the construction of metal-mediated supramolecular assemblies.

 Inorg. Chim. Acta, 2009, 362, 820-832.

  2) I. Bratsos, E. Alessio

 Ruthenium(II)-chlorido complexes of dimethylsulfoxide

 Inorg. Synth., 2010, 35, 148-152 (doi: 10.1002/9780470651568.ch8).

 3) E. Iengo,* T. Gatti, E. Zangrando, M. T. Indelli, F. Scandola, E. Alessio*

 Concerted motions in supramolecular systems: metal-mediated assemblies of porphyrins that behave like nanometric step-machines.

 Chem. Commun. 2011, 47, 1616-1618 (DOI: 10.1039/c0cc03513k)

4) E. Alessio, M. Casanova, E. Zangrando, E. Iengo*

 Modular self-assembled multiporphyrin cages with tunable shape.

 Chem. Commun.2012, 48, 5012-5015.

5) I. Finazzi, I. Bratsos, T. Gianferrara, A. Bergamo, N. Demitri, G. Balducci, E. Alessio*

 Photolabile Ru^II Half-Sandwich Complexes Suitable for Developing “Caged” Compounds: Chemical Investigation and Unexpected Dinuclear Species with Bridging Diamine Ligands.

 Eur. J. Inorg. Chem. 2013, 4743–4753. DOI:10.1002/ejic.201300792

6) I. Bratsos, S. Calmo, E. Zangrando, G. Balducci, E. Alessio*

 New cationic and neutral Ru(II)- and Os(II)-dmso carbonyl compounds.

 Inorg. Chem. 2013, 52, 12120–12130. DOI: 10.1021/ic401940z

 7) E. Iengo, N. Demitri, G. Balducci, E. Alessio*  

 An irresolute linker: separation, and structural and spectroscopic characterization of the two linkage isomers of a Ru(II)-(2-(2′-pyridyl)pyrimidine-4-carboxylic acid) complex.

 Dalton Trans. 2014, 43, 12160-12163. DOI: 10.1039/C4DT01282H.