Linea di ricerca "Sviluppo di complessi metallici per applicazioni in diagnostica e terapia"
Pubblicazioni pertinenti dal 2009
1) T. Gianferrara, I. Bratsos, E. Alessio*
A Categorization of Metal Anticancer Compounds Based on Their Mode of Action.
Dalton Trans., 2009, 7588-7598. Perspective Article
2) T. Gianferrara, I. Bratsos, E. Iengo, B. Milani, A. Oštrić, C. Spagnul, E. Zangrando, E. Alessio*
Synthetic strategies towards ruthenium-porphyrin conjugates for anticancer activity.
Dalton Trans., 2009, 10742-10756.
3) T. Gianferrara, A. Bergamo, I. Bratsos, B. Milani, C. Spagnul, G. Sava, E. Alessio
Ruthenium-porphyrin conjugates with cytotoxic and phototoxic antitumor activity.
J. Med. Chem., 2010, 53, 4678-4690.
4) I. Bratsos, T. Gianferrara, E. Alessio,* C. G. Hartinger, M. A. Jakupec, B. K. Keppler
Ruthenium and Other Non-platinum Anticancer Compounds.
in Bioinorganic Medicinal Chemistry, E. Alessio ed., Wiley-VCH, Weinheim, 2011, pp. 151-174.
5) I. Bratsos,* D. Urankar, E. Zangrando, P. Genova-Kalou, J. Košmrlj, E. Alessio, I. Turel*
1-(2-picolyl)-substituted 1,2,3-triazole as novel chelating ligand for the preparation of ruthenium complexes with potential anticancer activity.
Dalton Trans. 2011, 40, 5188 – 5199.
6) I. Bratsos,* C. Simonin, E. Zangrando, T. Gianferrara, A. Bergamo, E. Alessio*
New half sandwich-type Ru(II) coordination compounds characterized by the fac-Ru(dmso-S)3 fragment: influence of the face-capping group on the chemical behavior and in vitro anticancer activity.
Dalton Trans. 2011, 40, 9533 – 9543.
7) I. Bratsos,* E. Mitri, F. Ravalico, E. Zangrando, T. Gianferrara, A. Bergamo, E. Alessio*
New half sandwich Ru(II) coordination compounds for anticancer activity
Dalton Trans. 2012, 41, 7358 – 7371.
8) A. Rilak, I. Bratsos,* E. Zangrando, J. Kljun,I. Turel, Ž. D. BugarÄić, E. Alessio*
Factors that influence the antiproliferative activity of half sandwich RuII-[9]aneS3coordination compounds: activation kinetics and interaction with guanine derivatives.
Dalton Trans. 2012, 41, 11608 – 11618.
9) G. Ragazzon, I. Bratsos, E. Alessio,* L. Salassa,*A. Habtemariam, R. McQuitty, G. J. Clarkson, P. J. Sadler*
Design of Photoactivatable Metallodrugs: Selective and Rapid Light-induced Ligand Dissociation from Half-Sandwich [Ru([9]aneS 3 )(N–N')(py)]2+ Complexes.
Inorg. Chim. Acta 2012, 393, 230-238.
10) C. Spagnul, R. Alberto,* G. Gasser, S. Ferrari, V. Pierroz, A. Bergamo, T. Gianferrara,* E. Alessio
Novel water-soluble 99mTc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging.
J. Inorg. Biochem. 2013, 122, 57–65.
11) I. Finazzi, I. Bratsos, T. Gianferrara, A. Bergamo, N. Demitri, G. Balducci, E. Alessio*
Photolabile RuII Half-Sandwich Complexes Suitable for Developing “Caged†Compounds: Chemical Investigation and Unexpected Dinuclear Species with Bridging Diamine Ligands.
Eur. J. Inorg. Chem. 2013, 4743–4753. DOI:10.1002/ejic.201300792
12) J. Kljun,I. Bratsos, E. Alessio, G. Psomas, U. Repnik, M. Butinar, B. Turk, I. Turel*
New Uses for Old Drugs: Attempts to Convert Quinolone Antibacterials into Potential Anticancer Agents Containing Ruthenium.
Inorg. Chem. 2013, 52, 9039–9052. DOI: 10.1021/ic401220x
13) T. Gianferrara, C. Spagnul,R. Alberto,* G. Gasser,S. Ferrari, V. Pierroz, A. Bergamo, E. Alessio*
Towards matched pairs of porphyrin-Re(I)/99mTc(I) conjugates that combine photodynamic activity with fluorescence- and radio-imaging.
ChemMedChem 2014, 9, 1231–1237.DOI: 10.1002/cmdc.201300501.
14) A. Rilak, I. Bratsos,* E. Zangrando, J. Kljun, I. Turel, ZÌŒ. D. BugarcÌŒicÌ, E. Alessio*
New Water-Soluble Ruthenium(II) Terpyridine Complexes for Anticancer Activity: Synthesis, Characterization, Activation Kinetics, and Interaction with Guanine Derivatives.
Inorg. Chem. 2014, 53, 6113–6126. DOI 10.1021/ic5005215.
15) S. Pillozzi, L. Gasparoli, M. Stefanini, M. D’Amico, M. Ristori, E. Alessio, F. Scaletti, A. Becchetti, A. Arcangeli*, L. Messori*
NAMI-A is Highly Cytotoxic Toward Leukaemia Cell Lines: Evidence of Inhibition of KCa3.1 Channels.
Dalton Trans. 2014, 43, 12150 – 12155. DOI:10.1039/C4DT01356E.
Linea di ricerca "Sviluppo di complessi metallici per fotocatalisi e per la costruzione di sistemi supramolecolari"
Pubblicazioni pertinenti dal 2009
1) E. Zangrando, N. Kulisic, F. Ravalico, I. Bratsos, S. Jedner, M. Casanova, E. Alessio*
New ruthenium(II) precursors with the tetradentate sulfur macrocycles tetrathiacyclododecane ([12]aneS4) and tetrathiacyclohexadecane ([16]aneS4) for the construction of metal-mediated supramolecular assemblies.
Inorg. Chim. Acta, 2009, 362, 820-832.
2) I. Bratsos, E. Alessio
Ruthenium(II)-chlorido complexes of dimethylsulfoxide
Inorg. Synth., 2010, 35, 148-152 (doi: 10.1002/9780470651568.ch8).
3) E. Iengo,* T. Gatti, E. Zangrando, M. T. Indelli, F. Scandola, E. Alessio*
Concerted motions in supramolecular systems: metal-mediated assemblies of porphyrins that behave like nanometric step-machines.
Chem. Commun. 2011, 47, 1616-1618 (DOI: 10.1039/c0cc03513k)
4) E. Alessio, M. Casanova, E. Zangrando, E. Iengo*
Modular self-assembled multiporphyrin cages with tunable shape.
Chem. Commun.2012, 48, 5012-5015.
5) I. Finazzi, I. Bratsos, T. Gianferrara, A. Bergamo, N. Demitri, G. Balducci, E. Alessio*
Photolabile RuII Half-Sandwich Complexes Suitable for Developing “Caged†Compounds: Chemical Investigation and Unexpected Dinuclear Species with Bridging Diamine Ligands.
Eur. J. Inorg. Chem. 2013, 4743–4753. DOI:10.1002/ejic.201300792
6) I. Bratsos, S. Calmo, E. Zangrando, G. Balducci, E. Alessio*
New cationic and neutral Ru(II)- and Os(II)-dmso carbonyl compounds.
Inorg. Chem. 2013, 52, 12120–12130. DOI: 10.1021/ic401940z
7) E. Iengo, N. Demitri, G. Balducci, E. Alessio*
An irresolute linker: separation, and structural and spectroscopic characterization of the two linkage isomers of a Ru(II)-(2-(2′-pyridyl)pyrimidine-4-carboxylic acid) complex.
Dalton Trans. 2014, 43, 12160-12163. DOI: 10.1039/C4DT01282H.
Università degli studi di Trieste
