Avviso di Seminario: Silvia Marchesan - "Twists of chirality in short peptide self-assembled superstructures" - Edificio C11, Sala del Consiglio (1° piano)

Tipologia evento: 
Data evento
Data inizio evento: 
06/05/2015 - 15:30
Data fine evento: 
06/05/2015 - 16:30
Data pubblicazione evento
Pubblicato il: 


Mercoledì 6 MAGGIO 2015, ore 15:30, Edificio C11, Sala del Consiglio (I piano)



Dipartimento di Scienze Chimiche e Farmaceutiche


Twists of chirality in short peptide self-assembled superstructures



Self-assembly of small molecules into hydrogels is a hot topic of research that still presents many unanswered questions. In particular, tripeptides are very appealing building blocks that are simple to prepare and can encode powerful biological messages. However, prediction of their self-assembly behaviour is still a very challenging objective.1 Amongst the different tools that can be used to drive self-organisation, appropriate choice of chirality to fine-tune tripeptide molecular shape is an attractive yet mostly unexplored approach (Fig. 1). A different configuration at one stereocenter of simple hydrophobic sequences is sufficient to determine dramatic effects at macroscopic level (i.e., leading or not to a hydrogel within seconds).2 Importantly, specific nanostructure morphologies (e.g., nanotapes, twisted fibers) can be achieved through subtle molecular variations.3 The resulting assemblies hold high potential as biomaterials, as shown by their performance in vitro.4 This approach opens a number of innovative avenues, for example, through co-assembly with other molecules that actively participate in the superstructure.5

Fig. 1. Cryo-TEM images reveal different nanomorphologies for heterochiral tripeptide superstructures.



  1.  W. J. M. FrederixPim, G. G. Scott, Y. M. Abul-Haija, D. Kalafatovic, C. G. Pappas, N. Javid, N. T. Hunt, R. V. Ulijn and T. Tuttle, Nat. Chem., 2015, 7, 30-37.
  2.  S. Marchesan, L. Waddington, C. D. Easton, D. A. Winkler, L. Goodall, J. Forsythe and P. G. Hartley, Nanoscale, 2012, 4, 6752-6760.
  3.   S. Marchesan, C. D. Easton, F. Kushkaki, L. Waddington and P. G. Hartley, Chem. Commun., 2012, 48, 2195-2197.
  4.   S. Marchesan, C. D. Easton, K. E. Styan, L. J. Waddington, F. Kushkaki, L. Goodall, K. M. McLean, J. S. Forsythe and P. G. Hartley, Nanoscale, 2014, 6, 5172-5180.
  5.   S. Marchesan, Y. Qu, L. J. Waddington, C. D. Easton, V. Glattauer, T. J. Lithgow, K. M. McLean, J. S. Forsythe and P. G. Hartley, Biomaterials, 2013, 34, 3678-3687.


Ultimo aggiornamento: 04-05-2015 - 13:22